The abasic site as a target for generation of locally multiply damaged sites

Authors
Martelli, A Berthet, N Constant, JF Demeunynck, M Lhomme, J
Citation
A. Martelli et al., The abasic site as a target for generation of locally multiply damaged sites, BIOORG MED, 10(8), 2000, pp. 763-766
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
8
Year of publication
2000
Pages
763 - 766
Database
ISI
SICI code
0960-894X(20000417)10:8<763:TASAAT>2.0.ZU;2-Z
Abstract
Abasic sites in DNA have been specifically targeted by synthetic compounds able to cleave DNA at abasic sites and to induce photodamages in the vicini ty of the lesion. The synthesis and the photoactivity of the drugs on abasi c sites containing DNA and oligonucleotides are reported. (C) 2000 Elsevier Science Ltd. All rights reserved.