Synthesis and antibacterial activity of novel 6-O-substituted erythromycinA derivatives

Authors
Clark, RF Ma, ZK Wang, SY Griesgraber, G Tufano, M Yong, H Li, LP Zhang, XL Nilius, AM Chu, DTW Or, YS
Citation
Rf. Clark et al., Synthesis and antibacterial activity of novel 6-O-substituted erythromycinA derivatives, BIOORG MED, 10(8), 2000, pp. 815-819
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
8
Year of publication
2000
Pages
815 - 819
Database
ISI
SICI code
0960-894X(20000417)10:8<815:SAAAON>2.0.ZU;2-X
Abstract
A series of novel 6-O-substituted erythromycin A derivatives has been synth esized. Good in vitro antibacterial activity has been demonstrated for anal ogues incorporating a variety of structural features. The methodology discl osed is expected to find application in the design of future macrolide anti biotics that target the prevalent bacterial resistance problem. (C) 2000 El sevier Science Ltd. All rights reserved.