A convenient extension of the Wessely-Moser rearrangement for the synthesis of substituted alkylaminoflavones as neuroprotective agents in vitro

Authors
Larget, R Lockhart, B Renard, P Largeron, M
Citation
R. Larget et al., A convenient extension of the Wessely-Moser rearrangement for the synthesis of substituted alkylaminoflavones as neuroprotective agents in vitro, BIOORG MED, 10(8), 2000, pp. 835-838
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
8
Year of publication
2000
Pages
835 - 838
Database
ISI
SICI code
0960-894X(20000417)10:8<835:ACEOTW>2.0.ZU;2-Z
Abstract
A series of 8-alkylamino-5,7-dihydroxyflavones was prepared from chrysine v ia a seven step sequence. The synthesis of their B-alkylamino isomers could be subsequently accomplished through a convenient extension of the Wessely -Moser rearrangement. These compounds were found to be efficient neuroprote ctive agents in vitro. (C) 2000 Elsevier Science Ltd. All rights reserved.