Synthesis and antifungal activity of a ferrocene-fluconazole analogue

Authors
Biot, C Francois, N Maciejewski, L Brocard, J Poulain, D
Citation
C. Biot et al., Synthesis and antifungal activity of a ferrocene-fluconazole analogue, BIOORG MED, 10(8), 2000, pp. 839-841
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
8
Year of publication
2000
Pages
839 - 841
Database
ISI
SICI code
0960-894X(20000417)10:8<839:SAAAOA>2.0.ZU;2-P
Abstract
A novel ferrocene-fluconazole analogue was synthesized and its antifungal p roperties investigated against yeast strains of medical importance, includi ng those intrinsically resistant to fluconazole. In vitro tests revealed a slight increase in fungal growth and a reversal of the effect of fluconazol e at minimal inhibitory concentrations. (C) 2000 Elsevier Science Ltd. All rights reserved.