Electrostatic steering of substrate to acetylcholinesterase: Analysis of field fluctuations

Authors
Wlodek, ST Shen, TY McCammon, JA
Citation
St. Wlodek et al., Electrostatic steering of substrate to acetylcholinesterase: Analysis of field fluctuations, BIOPOLYMERS, 53(3), 2000, pp. 265-271
Citations number
21
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOPOLYMERS
ISSN journal
00063525 → ACNP
Volume
53
Issue
3
Year of publication
2000
Pages
265 - 271
Database
ISI
SICI code
0006-3525(200003)53:3<265:ESOSTA>2.0.ZU;2-X
Abstract
Based on previous molecular dynamics simulation results for acetylcholinest erase dimer, we calculate and analyse the electrostatic field fluctuations around the enzyme. The results show that dynamic features of the electrosta tic field Sal ou attraction of the positively-charged substrate. An interne t link to an animation of the results; is also provided. (C) 2000 John Wile y & Sons, Inc.