Postradiation squamous cell cancer of the breast

Primary squamous cell carcinoma of the breast is a rare clinical entity. We diagnosed a patient who presented with a pure squamous cell cancer of the breast 12 years after local radiation for a primary adenocarcinoma of breas t. Previously reported cancers related to radiation of the breast have been squamous cell of skin and esophagus and sarcomas, especially angiosarcomas , and on literature review this is the first reported case of primary squam ous carcinoma of the breast related to previous radiation. Although our obs ervation suggests a possible link, no established cause and effect relation ship is known at this point.