Investigation of retention and chiral recognition mechanism of the derivative beta-cyclodextrin bonded stationary phase

A partially substituted beta-CD CSP was prepared by the reaction of phenyl isocyanate(CSP1). The enantiomers of a series of diphenyl 1-(N-benzoxycarbo nyl)aminoalkanephosphonates were studied on CSP1 and a commercial (S)-(+)-( 1-naphthyl) ethylcarbamate derivative beta-CD bonded phase (CSP2) under nor mal phase condition, In order to compare the different chromatographic prop erty between the two CSPS, four molecular describing parameters reflecting the properties of the solutes were chosen to correlate against the experime ntal log k' value to form the QSERRs through the stepwise multivariable reg ression analysis. Each describing parameter in QSERRs model characterizes a kind of interaction in the chromatographic process, and the regression coe fficients of these describing parameters relate to the magnitude of the int eractions. The retention and enantioselectivity on both columns were examin ed and compared combining with the characteristic structure of the differen t derivative group on beta-CD.