P. Rigotti et al., Mycophenolate mofetil (MMF) versus azathioprine (AZA) in pancreas transplantation: a single-center experience, CLIN NEPHR, 53(4), 2000, pp. B52-B54
Aim: Advances in immunosuppression and careful monitoring for rejection are
largely responsible for improved results in pancreas transplantation. We c
onducted a retrospective study to establish the effectiveness of immunosupp
ressive therapy with mycophenolate mofetil (MMF) instead of azatioprine (AZ
A) in pancreas transplantation and to assess adverse effects in the two dif
ferent immunosuppressive regimes. Subjects and methods, Since 1991,27 pancr
eas transplantations were performed in 25 patients at our Institute. For in
duction therapy, immunosuppressant protocol consisted of quadruple immunosu
ppressive therapy with cyclosporine, steroids, antilymphocyte globulin and
AZA in 13 patients or MMF in 12 patients respectively. Results: Acute rejec
tion occurred in 76% of patients in the AZA group compared with 53% in the
MMF group. Steroid-resistant rejection was observed in 7% in the MMF group
compared to 38% of patients on AZA (p < 0.01). Two kidney grafts were lost
due to acute rejection in the AZA group, one pancreas was lost due to acute
rejection and one to chronic rejection in the MMF group. There were no sig
nificant differences in CMV infection. Severe fungal infections were noted
in 2 patients treated with MMF. Malignancy occurred in 1 patient (pancreas
graft lymphoma) in MMF. Conclusions: In conclusion, patients treated with M
MF required less frequent and less intensive treatment for acute rejection.
However, its short- and long-term side effects should be further investiga
ted.