Central motor conduction to lower limb after transcranial magnetic stimulation in spinocerebellar ataxia type 2 (SCA2)

Objectives: To evaluate central motor conduction to lower limbs in spinocer ebellar ataxia type 2 (SCA2). Methods: Transcranial magnetic stimulation was performed to study the corti cospinal tracts of 18 patients with SCA2. Results: Central motor conduction time (CMCT) to lower limbs and thresholds were abnormal in 8 patients (44%); CMCT and thresholds were significantly correlated with disease duration and disability. Conclusions: Corticospinal tract involvement is more frequent than previous ly reported in SCA2. Prolonged CMCT and increased threshold should not be u sed to differentiate between various type of autosomal dominant cerebellar ataxia. Similar to that reported in Friedreich's ataxia, we suggest that ex amining central motor conduction to the lower limbs may assist in evaluatin g the progressive steps of neurodegeneration in SCA2. (C) 2000 Elsevier Sci ence Ireland Ltd. All rights reserved.