Metachronous carcinoma of the vulva and fallopian tube

Background. Metachronous carcinoma of the vulva and fallopian tube is an un usual co-occurrence of gynecological malignancies. A report of such a case that developed and recurred over a 7-year period is presented. Case. A 53-year-old G3P3 female presented with a verrucous carcinoma of the vulva and a serous papillary adenocarcinoma of the left fallopian tube met achronously. To investigate a possible association between the co-occurrenc e of the rare neoplasms and factors associated with multiple gynecological malignancies, we analyzed the status of human papillomavirus infection and DNA mismatch repair deficiency as indicated by microsatellite instability. All samples analyzed were negative for these factors. Conclusion. The present results support the possibility that metachronous c arcinomas of the vulva and fallopian tube involve unknown etiological facto rs or arise independently. (C) 2000 Academic Press.