Ln. Yatham et al., GROWTH-HORMONE RESPONSE TO SUMATRIPTAN (5-HT1D AGONIST) CHALLENGE IN SEASONAL AFFECTIVE-DISORDER - EFFECTS OF LIGHT THERAPY, Biological psychiatry, 42(1), 1997, pp. 24-29
To explore the role of serotonergic system in seasonal affective disor
der (SAD), we compared growth hormone (GH) responses to a challenge wi
th a novel 5-HT1D receptor agonist sumatriptan between 11 patients wit
h SAD and nine healthy controls. Of the 11 patients with SAD, nine had
repeat sumatriptan challenge following treatment with light therapy.
The results showed that GH responses were significantly blunted during
winter depression in patients with SAD compared to healthy controls,
The GH responses normalized following treatment with light therapy to
similar levels in controls. The results of this study provide a suppor
t for the role of serotonergic system in pathophysiology of SAD and in
the mechanism of action of light therapy. (C) 1997 Society of Biologi
cal Psychiatry.