Free DNA induces modification on the protein synthesis profile of human peripheral blood mononuclear cells of healthy donors

Understanding how free DNA might act as a signal between cells is important for knowing how DNA orchestrates immune responses and for optimizing the t herapeutic of cancer, infection and immunologic diseases. This communicatio n demonstrates that DNAs from different origins (bacteria, T. cruzi, HeLa c ells) and synthetic oligonucleotide containing an unmethylated CPG motif ar e capable of inducing alterations in the protein profile of normal human le ukocytes. As far as we know there have been no similar studies regarding th e comparative effects of different free DNAs on early protein synthesis of human peripheral blood mononuclear cells.