Comparative in vitro activity of gemifloxacin

Gemifloxacin is a new quinolone and, like moxifloxacin, trovafloxacin, grep afloxacin and clinafloxacin, is more potent in vitro than ciprofloxacin or ofloxacin against Gram-positive aerobes, Gemifloxacin was the most potent o f the quinolones tested against streptococci and most ciprofloxacin-resista nt pneumococci were susceptible to gemifloxacin. Gemifloxacin, like moxiflo xacin, trovafloxacin, grepafloxacin and clinafloxacin, was more potent than ciprofloxacin or ofloxacin against all staphylococci and many ciprofloxaci n-resistant isolates were susceptible to these quinolones. Against Gram-neg ative aerobes gemifloxacin was as potent as or slightly less potent than ci profloxacin, and isolates resistant to ciprofloxacin were also resistant to gemifloxacin and to moxifloxacin, trovafloxacin and grepafloxacin. Gemiflo xacin was also the most potent quinolone against Gram-positive anaerobes an d fusobacteria but trovafloxacin was the most potent agent tested against o ther Gram-negative anaerobes.