Df. Sahm et al., Resistance surveillance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated in Asia and Europe, 1997-1998, J ANTIMICRO, 45(4), 2000, pp. 457-466
A multicentre, collaborative study was performed in Asia and Europe during
the winter of 1997-1998 to determine the in vitro activity of selected anti
microbial agents against common respiratory pathogens. Streptococcus pneumo
niae, Haemophilus influenzae and Moraxella catarrhalis isolates were collec
ted from 48 sites in China, France, Germany, Italy, Japan, Spain and the UK
and tested in a central laboratory in the USA. Broth microdilution MICs we
re determined for beta-lactams (penicillin, amoxycillin/clavulanate, cefuro
xime, ceftriaxone), macrolides (azithromycin, clarithromycin), sulphonamide
s (co-trimoxazole), glycopeptides (vancomycin) and fluoroquinolones (levofl
oxacin). The percentage of isolates susceptible to each antimicrobial class
varied substantially by country. Penicillin susceptibility amongst pneumoc
occi ranged from 34% in France and Spain to 92% in Germany, and macrolide s
usceptibility varied between 26% in China and 91% in the UK. In most countr
ies beta-lactam, macrolide and cotrimoxazole resistance was more prevalent
amongst penicillin-intermediate and -resistant S. pneumoniae isolates. Howe
ver, little or no resistance was detected to levofloxacin (0.3% intermediat
e and resistant) or vancomycin (0% intermediate and resistant). For H. infl
uenzae the prevalence of beta-lactamase production varied from 6% in China
and Germany to 32% in Spain, and for M. catarrhalis, from 79% in Germany to
98% in Japan. With the exception of ampicillin, beta-lactamase production
had a minimal effect on beta-lactam activity against H. influenzae or M. ca
tarrhalis. Our findings demonstrate that antimicrobial resistance profiles
of common respiratory isolates differ dramatically between countries in Asi
a and Europe.