Hs. Seong et al., Synthesis of a quaternary ammonium derivative of chito-oligosaccharide as antimicrobial agent for cellulosic fibers, J APPL POLY, 76(14), 2000, pp. 2009-2015
A derivative of chito-oligosaccharide (COS), N-(2-hydroxyl)propyl-3-trimeth
yl ammonium chito-oligosaccharide chloride (HTACC), was synthesized using a
reaction of glycidyltrimethylammonium chloride (GTMAC) and COS prepared by
depolymerization of a fully deacetylated chitosan. COS and HTACC were appl
ied to the cotton fabrics with a pad-dry-cure process using the reaction be
tween the hydroxyl group of cellulose and terminal aldehyde group in COS an
d HTACC. Their minimum inhibition concentration (MIC) was evaluated, and th
e antimicrobial activity and durability to laundering of cotton fabrics tre
ated with them were compared. The complete substitution of NH2 groups in CO
S with GTMAC was obtained at a 4 : 1 mol ratio of GTMAC to NH2 in 18 h at 8
0 degrees C under the presence of acetic acid. MIC values of the 1.04 DS of
HTACC and COS were 50 and 400 mu g/mL, respectively. A cotton fabric treat
ed with 0.2% of HTACC and 1.8% of COS exhibited 100% reduction of bacteria.
At the 50th laundering cycle, 0.3% of HTACC and 2.4% of COS indicated 100%
bacterial reduction. (C) 2000 John Wiley & Sons, Inc.