Substance abuse among working adults represents billions of dollars in prev
entable health cave costs and industry financial loss. Therefore, it is imp
erative to develop and test effective substance abuse prevention programs f
or the workplace. However applied workplace substance abuse prevention rese
arch is fraught with numerous methodological challenges. This article highl
ights a number of these challenges, which include (1) reaching a broad audi
ence with prevention messages, (2) handling the concerns of the employer (3
) collecting substance use data in the workplace (4) accessing and using re
cords-based data, and (5) linking survey and records-based data. Using exam
ples from the authors' ongoing research assessing a workplace health promot
ion and substance abuse prevention program funded by the Substance Abuse an
d Mental Health Services Administration's Center for Substance Abuse Preven
tion, the authors address these challenges.