The Risk Factor Profile combines single-site bone density assessment and se
lected clinical risk factors to help estimate the risk of osteoporotic frac
ture for Caucasian postmenopausal women over the next 5 years. The bone den
sity assessment uses T score cut-off values equivalent to the WHO definitio
ns of osteoporosis and osteopenia at the hip that would identify 16-17% of
women over 50 years of age as "high" risk, The clinical risk factors are de
fined as "major" producing about a doubling of fracture risk independent of
bone density, and "minor" where the predictive power is less certain. The
indications for a risk factor assessment using the Profile are the same as
for any bone density assessment with the exception of monitoring response t
o treatment. In practice the clinical risk factors can be measured at the t
ime of the bone density estimation taking only a few minutes. The decision
to treat, or not to treat, a postmenopausal woman at high or medium risk wi
ll ultimately depend on the overall assessment of risks and benefits, costs
of treatment and the desires of the patient. The Risk Factor Profile aims
to supply the clinician with a simple tool to aaid treatment decision-makin
g.