Based on a hypothesis of neural system involvement in the initial absorptio
n and further processing of the millimeter electromagnetic waves (MW) signa
l, we reproduced, quantitatively assessed and compared the analgesic effect
of a single MW treatment, exposing areas of skin possessing different inne
rvation densities. The cold water tail flick test (cTFT) was used to assess
experimental pain in mice. Three areas of exposure were used: the nose, th
e glabrous skin of the right footpad, and the hairy skin of the mid back at
the level of T5-T10. The MW exposure characteristics were: frequency = 61.
22 GHz; incident power density = 15mW/cm(2); and duration = 15 min. The max
imum hypoalgesic effect was achieved by exposing to MW the more densely inn
ervated skin areas - the nose and the footpad. The hypoalgesic effect in th
e cTFT after MW exposure to the murine back, which is less densely innervat
ed, was not statistically significant. These results support the hypothesis
of neural system involvement in the systemic response to MW.