The effect of selenium and/or vitamin E treatments on radiation-induced intestinal injury in rats

Citation
U. Mutlu-turkoglu et al., The effect of selenium and/or vitamin E treatments on radiation-induced intestinal injury in rats, LIFE SCI, 66(20), 2000, pp. 1905-1913
Citations number
29
Categorie Soggetti
Biochemistry & Biophysics
Journal title
LIFE SCIENCES
ISSN journal
00243205 → ACNP
Volume
66
Issue
20
Year of publication
2000
Pages
1905 - 1913
Database
ISI
SICI code
0024-3205(20000407)66:20<1905:TEOSAV>2.0.ZU;2-6
Abstract
Cytotoxic effects of ionizing radiation on gastrointestinal epithelium may be related to oxidative stress. In this study, we wanted to investigate the effects of selenium, vitamin E and selenium plus vitamin E pretreatments p rior to whole abdominal irradiation on intestinal injury. Irradiation cause d increased lipid peroxide and decreased GSH levels in the intestine. Intes tinal superoxide dismutase and glutathione peroxidase activities were incre ased, but glutathione transferase activity decreased following irradiation. Selenium and/or vitamin E pretreatments ameliorated these disturbances in prooxidant-antioxidant balance. This amelioriation has been verified with h istopathological findings. These results indicate that antioxidant pretreat ments prior to irradiation may have some beneficial effects against irradia tion-induced intestinal injury.