Metabolic defects caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and by HPTP (the tetrahydropyridinyl analog of haloperidol), in rats

Authors
Petzer, JP Bergh, JJ Mienie, LJ Castagnoli, N Van der Schyf, CJ
Citation
Jp. Petzer et al., Metabolic defects caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and by HPTP (the tetrahydropyridinyl analog of haloperidol), in rats, LIFE SCI, 66(20), 2000, pp. 1949-1954
Citations number
20
Categorie Soggetti
Biochemistry & Biophysics
Journal title
LIFE SCIENCES
ISSN journal
00243205 → ACNP
Volume
66
Issue
20
Year of publication
2000
Pages
1949 - 1954
Database
ISI
SICI code
0024-3205(20000407)66:20<1949:MDCB1(>2.0.ZU;2-K
Abstract
The results of previous studies in the baboon have suggested that HPTP, the tetrahydropyridinyl analog of haloperidol causes a urinary biochemical mar ker profile similar to those seen in humans suffering from inborn errors of mitochondrial respiration. In order to identify a possible relationship be tween compromized cellular energy production and neuronal damage we now hav e compared the urinary profiles of rats treated with the pro-neurotoxin, MP TP as well as with HPTP. Significantly increased urinary excretion of lacti c acid and 2-ethylhydracrylic acid in MPTP and HPTP treated rats was observ ed, indicating that both MPTP and HPTP and/or their respective metabolites cause mitochondrial inhibition in the rat.