This paper reviews the sources, identification and pharmacokinetics of hord
enine. This biogenic amine is generated during the breakdown of tyramine be
ginning on the first day of barley germination. It is contained in Cacti as
well as in different kinds of reeds (arundinacea, canaris, and aquatica) i
ncluding a variety of species cultivated in Poland (such as Motycka, Nakiel
ska, and Pulawska) which contain substantial quantities of hordenine.
Horse Racing Organisations in some countries consider this chemical compoun
d to be a stimulant, yet in fact, hordenine from natural food stuffs contai
ned in feed can reach a concentration of up to 18-90 mu g/ml in urea and up
to 1 mu g/ml in serum.
The pharmacological profile of hordenine shows that its stimulatory action
on the respiratory and cardiovascular systems is short-lived and appears on
ly when a high dose of the compound is used.
Because the effects are limited in time, the compound does not alter psycho
motor activity in horses. It seems that hordenine is not a stimulant in the
strict sense of the word. No data is available showing its stimulatory eff
ect on isolated limbs or on muscle activity.
Horses which were given 1 kg barley per day (hordenine content approximate
to 0,05% d.m.) could receive approximately 500 mg hordenine (approximate to
1 mg/kg B.W.).