How to produce systematic reviews of great quality and define evidenced based nephrology

Since recent years, a number of systematic reviews have been published in t he renal field. These publications will be used to develop the concept of e vidence based nephrology. The design and quality of renal systematic review s relies on technical skills and efficient trials search. The reasons for d iscrepancies that are sometimes reported between systematic reviews and con trolled clinical trials are now better understood and may be partly explain ed by inadequate trial recovery and publication biases. The applicability o f evidence findings is not always an easy task on patients level. The examp le of the low protein diet in chronic renal failure highlights such caveats . However, producing high level systematic reviews in the renal field may b e of great help to clarify the use of controversial treatments and to desig n new studies in the renal field.