The difference in temporal distribution of c-Fos immunoreactive neurons between the medullary dorsal horn and the trigeminal subnucleus oralis in therat following experimental tooth movement
Y. Fujiyoshi et al., The difference in temporal distribution of c-Fos immunoreactive neurons between the medullary dorsal horn and the trigeminal subnucleus oralis in therat following experimental tooth movement, NEUROSCI L, 283(3), 2000, pp. 205-208
The difference in temporal distribution of c-fos-immunoreactivity (Fos-IR)
was assessed in the medullary dorsal horn (MDH) and in the dorsomedial part
of the trigeminal subnucleus oralis (Vodm) following experimental tooth mo
vement of the rat maxillary molars. The number of MDH c-Fos-immunoreactive
neurons increased bilaterally at 2 h and decreased markedly by 12 h, and th
en increased again with a small peak at 48 h. In contrast, Vodm c-Fos expre
ssion was not up-regulated until 12 h, but increased in number after 24 h,
which increase lasted until 72 h. These findings indicate that experimental
tooth movement induced nociceptive c-Fos response in a biphasic manner. Fu
rthermore, the later response appeared after 24 h, and lasted for a few day
s, mainly manifested in the Vodm during experimental tooth movement. (C) 20
00 Elsevier Science Ireland Ltd. All rights reserved.