Differential effects of quinolinic acid lesions of the medial prefrontal cortex on the expression of morphine- and dizocilpine-induced behavioural plasticity in the rat
Tm. Tzschentke et Wj. Schmidt, Differential effects of quinolinic acid lesions of the medial prefrontal cortex on the expression of morphine- and dizocilpine-induced behavioural plasticity in the rat, NEUROSCI L, 283(2), 2000, pp. 125-128
Development and expression of behavioural sensitization have been shown to
be differentially affected by drugs and lesions. Here we assessed the effec
ts of quinolinic acid lesions of the rat medial prefrontal cortex on the ex
pression of enhanced locomotion and rearing that has been induced prior to
the lesions by 14 daily injections of morphine (10 mg/kg), dizocilpine (MK-
801) (0.3 mg/kg) or the combination of both drugs. Expression of tolerance
to morphine-induced behavioural inhibition was blocked by the lesions while
the expression of MK-801 -induced sensitization was not affected and the e
xpression of the sensitization induced by the drug combination was only mil
dly attenuated. These results suggest that the expression of behavioural pl
asticity induced by different drugs is mediated at least in part by differe
nt neural substrates. (C) 2000 Elsevier Science Ireland Ltd. All rights res
erved.