A series of amino-substituted methanofullerene derivatives were prepared by
mono, tris-, and hexa Bingel-Hirsch reactions using an N-protected malonat
e derivative, Upon scission of the protecting groups, the e,e,e-tris- and o
ctahedral T-h hexa-methano amino fullerenes were found to be among the most
water-soluble fullerene derivatives yet prepared. He-3 NMR data on corresp
onding adducts of He-3@C-60 helped verify the assigned structures. UV spect
ral studies confirmed the influence of aggregation on solubility of these a
dducts in water.