Dynamic kinetic resolution of alpha-hydroxy acid esters

Authors
Huerta, FF Laxmi, YRS Backvall, JE
Citation
Ff. Huerta et al., Dynamic kinetic resolution of alpha-hydroxy acid esters, ORG LETT, 2(8), 2000, pp. 1037-1040
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
8
Year of publication
2000
Pages
1037 - 1040
Database
ISI
SICI code
1523-7060(20000420)2:8<1037:DKROAA>2.0.ZU;2-E
Abstract
Enzymatic resolution in combination with ruthenium-catalyzed racemization o f the substrate led to dynamic kinetic resolution of alpha-hydroxy esters i n good yields and excellent ee's, Studies of different parameters showed th at the best results were obtained using Pseudomonas cepacia lipase, rutheni um catalyst 3, and 4-chlorophenyl acetate as acyl donor in cyclohexane.