delta-amino beta-keto esters, a designed polyfunctionalized chiral building block for alkaloid synthesis. Asymmetric synthesis of (R)-(+)-2-phenylpiperidine and (-)-SS20846A
Fa. Davis et al., delta-amino beta-keto esters, a designed polyfunctionalized chiral building block for alkaloid synthesis. Asymmetric synthesis of (R)-(+)-2-phenylpiperidine and (-)-SS20846A, ORG LETT, 2(8), 2000, pp. 1041-1043
delta-Amino beta-keto esters 3 and 11 are designed polyfunctionalized chira
l building blocks for alkaloid synthesis and are prepared in one step from
the corresponding sulfinimine (N-sulfinyl imine). Concise highly enantiosel
ective four step syntheses of 2-phenylpiperidine (7) and SS20846A (14) from
3 and 11, respectively, are described.