Solid-phase synthesis of carbocyclic nucleosides

An efficient solid phase synthesis of carbocyclic nucleosides has been deve loped. The key step is the palladium catalyzed coupling of a purine derivat ive to a resin bound allylic benzoate, The resulting products may be furthe r functionalized on the solid phase. Acidic cleavage affords carbocyclic nu cleosides, a class of compounds with demonstrated biological activity and s ubstantial current interest.