Synthesis of an anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem via stannatrane-mediated Stille coupling

Authors
Jensen, MS Yang, CH Hsiao, Y Rivera, N Wells, KM Chung, JYL Yasuda, N Hughes, DL Reider, PJ
Citation
Ms. Jensen et al., Synthesis of an anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem via stannatrane-mediated Stille coupling, ORG LETT, 2(8), 2000, pp. 1081-1084
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
8
Year of publication
2000
Pages
1081 - 1084
Database
ISI
SICI code
1523-7060(20000420)2:8<1081:SOAASA>2.0.ZU;2-J
Abstract
A short synthesis of carbapenem 1 is described. The key step involves the c ross-coupling of an enol triflate with an amino-substituted sp(3) carbon. T his cross-couping, which allows the introduction of the complete side chain in one step, utilizes a stannatrane as the heteroalkyl transfer reagent.