Palladium-catalyzed intermolecular coupling of aryl halides and amides

Authors
Yin, JJ Buchwald, SL
Citation
Jj. Yin et Sl. Buchwald, Palladium-catalyzed intermolecular coupling of aryl halides and amides, ORG LETT, 2(8), 2000, pp. 1101-1104
Citations number
18
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
8
Year of publication
2000
Pages
1101 - 1104
Database
ISI
SICI code
1523-7060(20000420)2:8<1101:PICOAH>2.0.ZU;2-G
Abstract
The first general intermolecular C-N bond-forming reactions between aryl ha lides and amides were realized using a palladium catalyst with Xantphos as the ligand, Aryl triflates, carbamates, and sulfonamides are also viable su bstrates for the amidations, which proceed at 45-110 degrees C with 1-4 mol % of Pd catalyst in 66-99% yields and exhibit good functional group compat ibility.