Communicating hydrocephalus in a patient with Gaucher's disease type 3

The case of a 3-year-old male with type 3 Gaucher's disease, whose genotype for the beta-glucosidase gene was D409H/unknown mutation, is presented, Af ter the onset of visceral and neurologic signs during infancy, a radiologic investigation at 3 Sears of age revealed communicating hydrocephalus, an u nusual complication of Gancher's disease. A ventriculoperitoneal shunt oper ation led to clinical and radiologic improvement. The possibility of this c omplication should be considered in the treatment of patients with Gaucher' s disease. (C) 2000 by Elsevier Science Inc. AII rights reserved.