Synthesis and pharmacological evaluation of prodrugs of valproic acid

Authors
Bodor, N Moon, SC Bruno-Blanch, L
Citation
N. Bodor et al., Synthesis and pharmacological evaluation of prodrugs of valproic acid, PHARMAZIE, 55(3), 2000, pp. 184-186
Citations number
17
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
55
Issue
3
Year of publication
2000
Pages
184 - 186
Database
ISI
SICI code
0031-7144(200003)55:3<184:SAPEOP>2.0.ZU;2-U
Abstract
We report the synthesis of (+/-)-3,6-Di-O-valproil-1,2: 4,5-di-O-isopropyli dene-myo-inositol (5) as well as (+/-)-3,6-Di-O- valproil-4,5-O-isopropylid ene-myo-inositol (6) and (+/-)-3,6-Di-O-valproil-myo-inositol (7), which re sults from acid hydrolysis of the formers. The anticonvulsant activity of t he compound 7 (MES test) expressed as ED50 is four times higher than that r eported for valproic acid.