2-RING DNA MINOR-GROOVE BINDERS CONSISTING OF READILY AVAILABLE, DISUBSTITUTED BENZENE-DERIVATIVES

Authors
YAN YF LIU M GONG B
Citation
Yf. Yan et al., 2-RING DNA MINOR-GROOVE BINDERS CONSISTING OF READILY AVAILABLE, DISUBSTITUTED BENZENE-DERIVATIVES, Bioorganic & medicinal chemistry letters, 7(11), 1997, pp. 1469-1474
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
11
Year of publication
1997
Pages
1469 - 1474
Database
ISI
SICI code
0960-894X(1997)7:11<1469:2DMBCO>2.0.ZU;2-#
Abstract
DNA minor-groove binders consisting of two disubstituted benzene rings were prepared. Two ligands showed sequence selectivities higher than some of the best known minor-groove binders containing six-membered ri ngs. Reversing the orientation of amide linkages in one ligand leads t o another one with relaxed binding to AT sequences and greatly increas ed affinity toward GC sequences. (C) 1997 Elsevier Science Ltd.