SYNTHESES AND ANTIVIRAL ACTIVITIES OF 1,3-DIOXOLANYLNUCLEOSIDE, 1,3-OXATHIOLANYLNUCLEOSIDE AND 1,3-DITHIOLANYLNUCLEOSIDE WITH 2-HYDROXYMETHYL SUBSTITUENTS

Authors
CHUN MW SHIN DH MOON HR LEE JW PARK H JEONG LS
Citation
Mw. Chun et al., SYNTHESES AND ANTIVIRAL ACTIVITIES OF 1,3-DIOXOLANYLNUCLEOSIDE, 1,3-OXATHIOLANYLNUCLEOSIDE AND 1,3-DITHIOLANYLNUCLEOSIDE WITH 2-HYDROXYMETHYL SUBSTITUENTS, Bioorganic & medicinal chemistry letters, 7(11), 1997, pp. 1475-1480
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
11
Year of publication
1997
Pages
1475 - 1480
Database
ISI
SICI code
0960-894X(1997)7:11<1475:SAAAO1>2.0.ZU;2-I
Abstract
Novel 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleoside s with 2-hydroxymethyl substituents (1a-4b) were each synthesized with good yields through the condensation of dinucleophiles (oxygen and/or sulfur) with 1,3-dibenzoxy-2-propanone methyl ketal as a key step. (C ) 1997 Elsevier Science Ltd.