pThe concept of multiple squamous cell carcinoma in the region of the upper
aerodigestive tract was first described over 100 years ago by Billroth. Th
e aim of our study was to assess the incidence of synchronous and metachron
ous second primary rumours and refine the role of panendoscopy in diagnosin
g them.
The charts of 358 patients presenting for initial treatment of primary squa
mous cell carcinoma of the upper aerodigestive tract between January 1990 a
nd December 1995 were reviewed. The incidence of second primary tumours was
16.2%, 6.4% being synchronous and 9.8% metachronous. In only 3.1% of all p
atients was a synchronous tumour clinically silent and only revealed by pan
endoscopy. Synchronous tumours were most likely to be located in the oral c
avity, pharynx or larynx (61%), whereas metachronous second primary tumours
were most likely to be located in the lung (57%). Though the incidence of
synchronous second primary rumours revealed by routine panendoscopy is low
(3%), we still recommend this investigation because it is often necessary f
or exact assessment of the first primary tumour. Further, it is ideal for t
raining in the use of rigid endoscopy. In our opinion panendos-copy involve
s minimal time, cost and morbidity.