Control of homeostasis of CD8(+) memory T cells by opposing cytokines

Authors
Ku, CC Murakami, M Sakamato, A Kappler, J Marrack, P
Citation
Cc. Ku et al., Control of homeostasis of CD8(+) memory T cells by opposing cytokines, SCIENCE, 288(5466), 2000, pp. 675-678
Citations number
45
Categorie Soggetti
Multidisciplinary,Multidisciplinary,Multidisciplinary
Journal title
SCIENCE
ISSN journal
00368075 → ACNP
Volume
288
Issue
5466
Year of publication
2000
Pages
675 - 678
Database
ISI
SICI code
0036-8075(20000428)288:5466<675:COHOCM>2.0.ZU;2-W
Abstract
Memory T cells maintain their numbers for long periods after antigen exposu re, Here we show that CD8(+) T cells of memory phenotype divide slowly in a nimals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2), Therefore, the numbers of CD8(+) memory T cells in animals are controlled by a balance between IL-15 and IL-2.