Objective. To determine the current management of hypertensive disorders of
pregnancy in South Africa.
Method. A postal questionnaire was sent to 600 South African obstetricians.
Results. The response rate was 72% (432/600) with 425 questionnaires suitab
le for analysis. South African obstetricians disagree on the definitions of
various hypertensive disorders of pregnancy. Methyldopa was the antihypert
ensive used most frequently for the treatment of mild to moderate hypertens
ion (diastolic blood pressure between 90 and 109 mmHg), while intravenous d
ihydralazine was preferred in severe hypertension (diastolic blood pressure
greater than or equal to 110 mmHg and proteinuria greater than or equal to
++).
To stop convulsions in eclampsia, 256 respondents (60%) said they would use
diazepam, 28 (11%) said they would continue with a diazepam infusion, and
the remaining 228 (89%) preferred magnesium sulphate (MgSO4) to prevent fur
ther convulsions. The intramuscular route was the preferred method of admin
istration for MgSO4.
In cases of eclampsia, 273 respondents (64%) said they would use intravenou
s dihydralazine to lower high blood pressure (greater than or equal to 160/
110 mmHg) and proteinuria; 98 respondents (23%) said they would use methyld
opa, 38 (9%) nifedipine, and 8 (2%) apresoline. Eight (2%) said they would
not use antihypertensives.
In patients with severe pre-eclampsia and impending eclampsia, 330 responde
nts (78%) said they would use MgSO4 as prophylaxis, 46 (11%) diazepam, and
6 (1.4%) phenobarbitone. Forty-three of the respondents did not prescribe p
rophylactic anticonvulsant therapy. To prevent pre-eclampsia, 247 of the re
spondents (58%) said they would prescribe low-dose aspirin.
Conclusion. This study demonstrates that South African obstetricians show g
reat uniformity in terms of the treatment of hypertensive disorders of preg
nancy.