The flourishing syntheses of non-nucleoside reverse transcriptase inhibitors

Authors
Pedersen, OS Pedersen, EB
Citation
Os. Pedersen et Eb. Pedersen, The flourishing syntheses of non-nucleoside reverse transcriptase inhibitors, SYNTHESIS-S, (4), 2000, pp. 479-495
Citations number
110
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
4
Year of publication
2000
Pages
479 - 495
Database
ISI
SICI code
0039-7881(200004):4<479:TFSONR>2.0.ZU;2-L
Abstract
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of increasing importance in the treatment of HIV-1 infected persons. In this review the f ocus is on the syntheses of the approved NNRTI drugs efavirenz, delavirdine , nevirapine, and their analogues. This review also deals with the synthese s of the most promising NNRTI candidates in clinical testing and with the s yntheses of subclasses of NNRTIs with known crystal structures when complex ed with the reverse transcriptase enzyme.