Synthesis of indolo[3,2-c]quinoline and pyrido[3 ',2 ': 4,5][3,2-c]quinoline derivatives

Authors
Mouaddib, A Joseph, B Hasnaoui, A Merour, JY
Citation
A. Mouaddib et al., Synthesis of indolo[3,2-c]quinoline and pyrido[3 ',2 ': 4,5][3,2-c]quinoline derivatives, SYNTHESIS-S, (4), 2000, pp. 549-556
Citations number
38
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
4
Year of publication
2000
Pages
549 - 556
Database
ISI
SICI code
0039-7881(200004):4<549:SOIAP'>2.0.ZU;2-N
Abstract
Potential antitumoral scaffold indolo[3,2-c]quinoline 5a was obtained by an intramolecular Heck cyclisation from the corresponding 2-iodophenyl-3-indo lecarboxamide 4a. The 7-azaindole analogue 5b was prepared by the same appr oach. Triflate displacement of compounds 6 according to Suzuki and Stille r eactions gave the 6-substituted derivatives 7-10.