A versatile approach to anti-asthmatic compound CMI-977 and its six-membered analogue

Authors
Gurjar, MK Krishna, LM Reddy, BS Chorghade, MS
Citation
Mk. Gurjar et al., A versatile approach to anti-asthmatic compound CMI-977 and its six-membered analogue, SYNTHESIS-S, (4), 2000, pp. 557-560
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
4
Year of publication
2000
Pages
557 - 560
Database
ISI
SICI code
0039-7881(200004):4<557:AVATAC>2.0.ZU;2-N
Abstract
The synthesis of the anti-asthmatic compound CMI-977 is described. The tetr ahydrofuran ring was effectively constructed by involving olefin metathesis while the stereoselective introduction of the 1-N-hydroxyureidylbut-3-yn-4 -yl side-chain was achieved by C-alkylation of the 2-benzenesulfonyl deriva tive.