Diterpenic alpha- and beta-hydroxybutanolides with antifeedant activity: semisynthesis and absolute configuration

Authors
Marcos, IS Gonzalez, JL Sexmero, MJ Diez, D Basabe, P Williams, DJ Simmonds, MSJ Urones, JG
Citation
Is. Marcos et al., Diterpenic alpha- and beta-hydroxybutanolides with antifeedant activity: semisynthesis and absolute configuration, TETRAHEDR L, 41(15), 2000, pp. 2553-2557
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
15
Year of publication
2000
Pages
2553 - 2557
Database
ISI
SICI code
0040-4039(20000408)41:15<2553:DAABWA>2.0.ZU;2-7
Abstract
Two series of ent-halimanolides (15,16-olides and 16,15-olides), analogues of biologically active diterpene lactones, were synthesized starting from e nt-halimic acid methyl ester. The absolute configuration was determined by CD spectroscopy and corroborated by X-ray analysis. Antifeedant testing has been carried out on these compounds. (C) 2000 Elsevier Science Ltd. All ri ghts reserved.