Studies on chemical modification of monensin. Part 7. Synthesis and Ca2+ ion transport activity of 25-carboxylmonensin

Authors
Nagatsu, A Tanaka, R Hashimoto, M Mizukami, H Ogihara, Y Sakakibara, J
Citation
A. Nagatsu et al., Studies on chemical modification of monensin. Part 7. Synthesis and Ca2+ ion transport activity of 25-carboxylmonensin, TETRAHEDR L, 41(15), 2000, pp. 2629-2632
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
15
Year of publication
2000
Pages
2629 - 2632
Database
ISI
SICI code
0040-4039(20000408)41:15<2629:SOCMOM>2.0.ZU;2-0
Abstract
Ionophore antibiotic monensin (1) was converted to 25-carboxylmonensin (3), which has two carboxyl groups at both ends of the molecule. Ca2+ ion trans port activity of 25-carboxylmonensin (3) was evaluated by the CHCl3 liquid membrane method, and the activity was 3.1 times the value of the calcium io nophore, lasalocid A. (C) 2000 Elsevier Science Ltd. All rights reserved.