The thrombogram: Monitoring thrombin generation in platelet rich plasma

Authors
Hemker, HC Giesen, PLA Ramjee, M Wagenvoord, R Beguin, S
Citation
Hc. Hemker et al., The thrombogram: Monitoring thrombin generation in platelet rich plasma, THROMB HAEM, 83(4), 2000, pp. 589-591
Citations number
23
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
THROMBOSIS AND HAEMOSTASIS
ISSN journal
03406245 → ACNP
Volume
83
Issue
4
Year of publication
2000
Pages
589 - 591
Database
ISI
SICI code
0340-6245(200004)83:4<589:TTMTGI>2.0.ZU;2-7
Abstract
A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the fluorescent split-produ ct of the substrate Z-Gly-Gly-Arg-AMC. The signal is not impaired by turbid ity; therefore proper measurement is not disturbed by the occurrence of a c lot or the presence of platelets and direct measurement in platelet rich pl asma is possible.