Links between replication, recombination and genome instability in eukaryotes

Authors
Flores-Rozas, H Kolodner, RD
Citation
H. Flores-rozas et Rd. Kolodner, Links between replication, recombination and genome instability in eukaryotes, TRENDS BIOC, 25(4), 2000, pp. 196-200
Citations number
48
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
25
Issue
4
Year of publication
2000
Pages
196 - 200
Database
ISI
SICI code
0968-0004(200004)25:4<196:LBRRAG>2.0.ZU;2-H
Abstract
Double-strand breaks in DNA can be repaired by homologous recombination inc luding break-induced replication. In this reaction, the end of a broken DNA invades an intact chromosome and primes DNA replication resulting in the s ynthesis of an intact chromosome. Break-induced replication has also been s uggested to cause different types of genome rearrangements.