M. Backlund et al., Effect of intra-aortic magnesium on renal function during and after abdominal aortic surgery: A pilot study, ACT ANAE SC, 44(5), 2000, pp. 605-611
Citations number
30
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Background: Infrarenal aortic cross-clamping causes renal vasoconstriction.
Magnesium may protect against renal deterioration through its vasodilatory
properties.
Methods: Thirty patients with normal preoperative renal function undergoing
infrarenal aortic cross-clamping for elective aortic surgery received magn
esium (4 mmol) or saline into the aorta immediately after aortic cross-clam
ping and again just before unclamping in a double-blind fashion. Pulmonary
artery occlusion pressure was maintained greater than or equal to 15 mmHg.
Five patients with magnesium were excluded due to need for intravenous nitr
oglycerine because of myocardial ischaemia during the study.
Results: Postoperative creatinine clearance remained unchanged in both grou
ps. Urinary N-acetyl-beta-D-glucosaminidase excretion increased before and
decreased after aortic crossclamping in both groups. The concentrations of
glutathione peroxidase in serum were identical between the two groups.
Conclusions:These data indicate that intra;aortic magnesium had no effect o
n renal function during or after aortic crossclamping. (C) Acta Anaesthesio
logica Scandinavica 44 (2000).