Oligodendrocytic gliomatosis cerebri

We describe a very unusual case of gliomatosis cerebri (GC) with oligodendr ocytic differentiation. A 65-year-old man presented with a convulsive seizu re. Magnetic resonance (MR) documented diffuse enlargement of cerebral hemi spheres, brainstem, and right cerebellar hemisphere. After admission, the p atient manifested a progressive deterioration of his neurological condition . A right temporal craniotomy and temporal lobectomy were performed to obta in brain decompression and diagnosis. Pathological findings were those of a GC consisting of neoplastic oligodendrocytes. Oligodendrocytic GC is a ver y rare pathological condition. Diagnosis of GC is usually made at autopsy. Our case confirms that diagnosis by a combination of MR imaging and brain b iopsy.