The medications most often implicated in prescription drug abuse are opioid
analgesics, sedative-hypnotics and stimulants. Patients with acute or chro
nic pain, anxiety disorders and attention-deficit disorder are at increased
risk of addiction comorbidity. It is important to ask patients about their
substance-use history, including alcohol, illicit drugs and prescription d
rugs. Patients who abuse prescription drugs may exhibit certain patterns, s
uch as escalating use, drug-seeking behavior and doctor shopping. A basic c
linical survival skill in situations in which patients exert pressure on th
e physician to obtain a prescription drug is to say "no" and stick with it.
Physicians who overprescribe can be characterized by the four "Ds"-dated,
duped, dishonest and disabled. Maintaining a current knowledge base, docume
nting the decisions that guide the treatment process and seeking consultati
on are important risk-management strategies that improve clinical care and
outcomes.