Contrast-enhanced color Doppler sonography for evaluation of enlarged cervical lymph nodes in head and neck tumors

OBJECTIVE. We determined whether contrast-enhanced color Doppler sonography can differentiate benign from malignant enlarged cervical lymph nodes in h ead and neck tumors. SUBJECTS AND METHODS. Ninety-four enlarged lymph nodes in 39 adult patients (32 men and seven women; age range, 30-81 years) were examined with B-mode sonography and with unenhanced and contrast-enhanced color Doppler sonogra phy. All patients had carcinoma of the oral cavity. Histologically, lymphad enitis was found in 57 nodes and metastases in 37 nodes. Geometric dimensio n, texture, and margin of the node and detection and location of vessels we re noted. Histology and imaging findings were correlated. RESULTS. The transverse-to-longitudinal diameter ratio in combination with texture and margin analysis resulted in a correct diagnosis in only approxi mately 79% of the nodes. With contrast-enhanced color Doppler sonography, 8 6% of nodes showed vessels, and 28% of nodes showed vessels with this techn ique exclusively. Characteristic configurations were identified: hilar vess els with branching indicated lymphadenitis (sensitivity, 98%; specificity, 100%), and predominantly peripheral vessels indicated metastases (100%, 98% ). These findings changed the diagnosis in 13 nodes, changed the therapy in four patients, and led to an incorrect diagnosis in one patient. CONCLUSION. Enlarged lymph nodes can be characterized as metastatic or infl ammatory with high diagnostic accuracy on the basis of their vascular archi tecture as seen on contrast-enhanced color Doppler sonography.