Comparative killing rates of fluoroquinolones and cell wall-active agents

Authors
Fung-Tomc, JC Gradelski, E Valera, L Kolek, B Bonner, DP
Citation
Jc. Fung-tomc et al., Comparative killing rates of fluoroquinolones and cell wall-active agents, ANTIM AG CH, 44(5), 2000, pp. 1377-1380
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
5
Year of publication
2000
Pages
1377 - 1380
Database
ISI
SICI code
0066-4804(200005)44:5<1377:CKROFA>2.0.ZU;2-3
Abstract
Killing rates of fluoroquinolones, beta-lactams, and vancomycin were compar ed against Enterobacteriaceae, Staphylococcus aureus, pneumococci, streptoc occi, and Enterococcus faecalis. The times required for fluoroquinolones to decrease viability by 3 log(10) were 1.5 h for Enterobacteriaceae, 4 to 6 h for staphylococci, and greater than or equal to 6 h for streptococci and enterococci. Thus, the rate of killing by fluoroquinolones is organism grou p dependent; overall, they killed more rapidly than beta-lactams and vancom ycin.