Pharmacokinetics and pharmacodynamics of levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in human skin blister fluid

Authors
Trampuz, A Wenk, M Rajacic, Z Zimmerli, W
Citation
A. Trampuz et al., Pharmacokinetics and pharmacodynamics of levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in human skin blister fluid, ANTIM AG CH, 44(5), 2000, pp. 1352-1355
Citations number
25
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
5
Year of publication
2000
Pages
1352 - 1355
Database
ISI
SICI code
0066-4804(200005)44:5<1352:PAPOLA>2.0.ZU;2-R
Abstract
The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SB F) was determined for 20 volunteers after a single 500-mg oral dose of levo floxacin. In addition, ex vivo bactericidal activity of SBF against Strepto coccus pneumoniae and Staphylococcus aureus was studied. SBF containing lev ofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacte ria and 2.0 log of Staphylococcus aureus bacteria during a 6-h incubation.